PANS/PANDAS Specialist

Optimal Health Spectrums -  - Integrative Wellness Clinic

Optimal Health Spectrums

Integrative Wellness Clinic located in Pleasanton, CA

PANDAS stands for pediatric autoimmune neuropsychiatric disorders associated with streptococcus. The syndrome involves sudden and often major changes in personality, behavior, and movement in children following an infection involving Streptococcus pyogenes (streptococcal-A infection). PANS is the acronym for Pediatric Acute-onset Neuropsychiatric Syndrome, a more recently defined disorder which encompasses the more familiar PANDAS. PANDAS is now considered a subset of the broader classification, PANS.


Most people with a strep infection recover without difficulty. However, some children develop sudden physical and psychiatric symptoms a few weeks after infection. Once they start, these symptoms tend to rapidly get worse. The symptoms include behaviors similar to obsessive-compulsive disorder (OCD) and Tourette syndrome. These symptoms can interfere with school and can quickly become debilitating.

Psychological symptoms may include:

  • obsessive, compulsive, and repetitive behaviors
  • separation anxiety, fear, and panic attacks
  • incessant screaming, irritability, and frequent mood changes
  • emotional and developmental regression
  • visual or auditory hallucinations
  • depression and suicidal thoughts

Physical symptoms may include:

  • tics and unusual movements
  • sensitivities to light, sound, and touch
  • deterioration of small motor skills or poor handwriting
  • hyperactivity or an inability to focus
  • memory problems
  • trouble sleeping
  • refusing to eat, which can lead to weight loss
  • joint pain
  • frequent urination and bedwetting
  • near catatonic state

Children with PANDAS usually don't have all of these symptoms, but they generally have a mix of them.

The National Institute of Mental Health (NIMH) acknowledged that PANS is a treatable autoimmune condition that could be triggered by any number of infections (other than strep) including Borrelia burgdorferi (Lyme disease), mycoplasma pneumonia, herpes simplex, the common cold, influenza and other viruses, and that patients could be diagnosed with the condition even if the infectious trigger(s) was unknown. 


The immunological reaction that occurs with PANS is believed to be similar to PANDAS. Exposure to any number of infectious agent(s) triggers a misdirected immune reaction, where antibodies attack a portion of the brain, causing inflammation. The inflammation, in turn, causes an abrupt onset of neuropsychiatric symptoms, such as obsessive-compulsive disorder, tics, severe eating restriction, anxiety, ADHD-type behaviors, personality changes, emotional lability, and sleep disturbance.


Unfortunately, many cases of PANS go unrecognized or are misdiagnosed. A child may be accused of fabricating or exaggerating their symptoms. Other doctors may attribute the personality changes to rebellious developmental stages or poor parenting. Typically, patients have seen multiple doctors in search of an answer. And, all too often, children suffering from PANS or PANDAS are diagnosed with a mental illness and prescribed psychiatric medications, which is not addressing the underlying cause.


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